氣道平滑肌是維持氣道張力的根本。它存在于氣管、支氣管樹直至終末支氣管。其特異的超微結(jié)構(gòu)特點和調(diào)節(jié)機制是實現(xiàn)氣管正常生理功能的基礎(chǔ)。有證據(jù)表明氣管平滑肌在肺的發(fā)育過程以及諸如**病、慢性支氣管炎和肺氣腫等疾病狀態(tài)下經(jīng)歷著顯著的表型變化。另外，氣道平滑肌通過分泌細胞因子和趨化因子等促炎介質(zhì)，發(fā)揮免疫調(diào)節(jié)功能。培養(yǎng)的氣管平滑肌細胞能表達三種P21活化的激酶（PAK）的同型異構(gòu)體和PAK1，并通過P38 mapk信號途徑參與氣管平滑肌細胞的遷移。氣道平滑肌細胞增殖已成為人們關(guān)注的焦點，因為在**病人中，此細胞是氣道壁重塑反應(yīng)中數(shù)量上的重要組分，并被認(rèn)為是新型抗**病藥物的作用目標(biāo)。
人氣管平滑肌細胞提取于人氣管組織，二代凍存。每管含有細胞數(shù)>5×105 cells/ml，此細胞通過對alpha-SMA和Desmin免疫熒光染色驗證，經(jīng)測試不含有HIV-1、HBV、HCV、支原體、細菌、酵母和真菌。細胞可以達到15倍增。? ?
推薦培養(yǎng)基：平滑肌細胞培養(yǎng)基 (SMCM, Cat. #1101)
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貨號
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3410
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產(chǎn)地
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美國
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縮寫
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HTSMC
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規(guī)格
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5 x 10^5 /1ml
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用途
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科研
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儲存
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液氮
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運輸
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干冰
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關(guān)鍵字
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人氣管平滑肌細胞 HTSMC 人氣管平滑肌細胞 HTSMC 人氣管平滑肌細胞 HTSMC 人氣管平滑肌細胞 HTSMC 人氣管平滑肌細胞 HTSMC 人氣管平滑肌細胞 HTSMC 人氣管平滑肌細胞 HTSMC 人氣管平滑肌細胞 HTSMC
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公司簡介
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合肥星肽生物科技有限公司作為專業(yè)的ScienCell中國代理商，專業(yè)經(jīng)營實驗室科研用原代細胞、原代細胞專用培養(yǎng)基、原代細胞無血清培養(yǎng)基、干細胞、干細胞培養(yǎng)基、干細胞無血清培養(yǎng)基的研究和開發(fā)。合肥星肽生物科技有限公司始終致力于為客戶提供可靠的研究材料以及方便快捷的服務(wù)，對購買項目的前期資料提供,中期合同保證,后期貨物跟蹤到*終售后的確保項目準(zhǔn)確到位，都有相關(guān)專業(yè)人士進行維護,確保您在合肥合肥星肽生物科技有限公司公司獲得*上等服務(wù)！
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聯(lián)系方式
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何經(jīng)理，合肥星肽生物科技有限公司，Tel：0551-63802898 400-8702-898，
E-mail：[email protected] http://www.cnqiepian.com QQ:514713116
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7.) Luo SF, Chang CC, Lee IT, Lee CW, Lin WN, Lin CC, Yang CM. (2009) "Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells."?Toxicol Appl Pharmacol. 237: 8-21.?
8.) Yang CM, Lee IT, Lin CC, Yang YL, Luo SF, Kou YR, Hsiao LD. (2009) "Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells."?Am J Physiol Lung Cell Mol Physiol. 297: L892-902.
9.) Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM. (2008) "Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells."?Mol Pharmacol. 73: 1454-64.
10.) Liang KC, Lee CW, Lin WN, Lin CC, Wu CB, Luo SF, Yang CM. (2007) "Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells."?J Cell Physiol. 211: 759-70.
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